YARS polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS8444
Background:
Tryptophanyl-tRNA synthetases are essential enzymes that catalyze the aminoacylation of tRNA(Trp) with tryptophan, an essential function of the cell’s protein synthesis machinery. Two forms of tryptophanyl-tRNA synthetase exist; a cytoplasmic form, named TrpRS (also known as WARS), and a mitochondrial form, named WARS2. In normal cells, human TrpRS exists as a full length form and as a truncated form designated mini TrpRS, which is produced by alternative splicing. Expression of mini TrpRS is highly stimulated in human cells by the addition of IFN-g. Although both human full length TrpRS and mini TrpRS are enzymatically active in aminoacylation, they differ in angiostatic activity. The tyrosyl-tRNA synthetase (TyrRS), a protein related to TrpRS, exists as a homodimeric enzyme that catalyzes the aminoacylation of tRNA(Tyr) by L-tyrosine.
Alternative Name:
Tyrosine--tRNA ligase, cytoplasmic, Tyrosyl-tRNA synthetase, TyrRS, YARS
Application Dilution: WB: 1:500 - 1:2000, IP: 1:50 - 1:200
Specificity: YARS polyclonal antibody detects endogenous levels of YARS protein.
Immunogen:
Recombinant full length Human YARS.
MW: ~ 59 kDa
Swis Prot.: P54577
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Tryptophanyl-tRNA synthetases are essential enzymes that catalyze the aminoacylation of tRNA(Trp) with tryptophan, an essential function of the cell’s protein synthesis machinery. Two forms of tryptophanyl-tRNA synthetase exist; a cytoplasmic form, named TrpRS (also known as WARS), and a mitochondrial form, named WARS2. In normal cells, human TrpRS exists as a full length form and as a truncated form designated mini TrpRS, which is produced by alternative splicing. Expression of mini TrpRS is highly stimulated in human cells by the addition of IFN-g. Although both human full length TrpRS and mini TrpRS are enzymatically active in aminoacylation, they differ in angiostatic activity. The tyrosyl-tRNA synthetase (TyrRS), a protein related to TrpRS, exists as a homodimeric enzyme that catalyzes the aminoacylation of tRNA(Tyr) by L-tyrosine.
Alternative Name:
Tyrosine--tRNA ligase, cytoplasmic, Tyrosyl-tRNA synthetase, TyrRS, YARS
Application Dilution: WB: 1:500 - 1:2000, IP: 1:50 - 1:200
Specificity: YARS polyclonal antibody detects endogenous levels of YARS protein.
Immunogen:
Recombinant full length Human YARS.
MW: ~ 59 kDa
Swis Prot.: P54577
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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