ZAP-70 (clone 4B2-C1-H3), anti-human

Background:
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Synonyms: ADMIO2, IMD48, SRK, STCD, STD, TZK, ZAP-70, SRK, STCD, STD, TZK, ZAP-70

Cellular Location: Cell membrane Cytoplasm Peripheral membrane protein

Immunogen:
Purified recombinant human ZAP-70 protein fragments expressed in E.coli.

Gene Symbol: ZAP-70

Gene ID: 7535

Swiss prot: P43403

Calculated MW: 70kDa

Recommended dilution:
WB 1:1000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.