ZAP70 Antibody (Center) Blocking peptide
€363.00
In stock
SKU
AC-BP14145c
Background:
This gene encodes an enzyme belonging to the proteintyrosine kinase family, and it plays a role in T-cell developmentand lymphocyte activation. This enzyme, which is phosphorylated ontyrosine residues upon T-cell antigen receptor (TCR) stimulation,functions in the initial step of TCR-mediated signal transductionin combination with the Src family kinases, Lck and Fyn. Thisenzyme is also essential for thymocyte development. Mutations inthis gene cause selective T-cell defect, a severe combinedimmunodeficiency disease characterized by a selective absence ofCD8-positive T-cells. Two transcript variants that encode differentisoforms have been found for this gene.
Other Names:
Tyrosine-protein kinase ZAP-70, 70 kDa zeta-chain associated protein, Syk-related tyrosine kinase, ZAP70, SRK
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP14145c was selected from the Center region of ZAP70. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ZAP70
Gene ID: 7535
Primary Accession: P43403
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes an enzyme belonging to the proteintyrosine kinase family, and it plays a role in T-cell developmentand lymphocyte activation. This enzyme, which is phosphorylated ontyrosine residues upon T-cell antigen receptor (TCR) stimulation,functions in the initial step of TCR-mediated signal transductionin combination with the Src family kinases, Lck and Fyn. Thisenzyme is also essential for thymocyte development. Mutations inthis gene cause selective T-cell defect, a severe combinedimmunodeficiency disease characterized by a selective absence ofCD8-positive T-cells. Two transcript variants that encode differentisoforms have been found for this gene.
Other Names:
Tyrosine-protein kinase ZAP-70, 70 kDa zeta-chain associated protein, Syk-related tyrosine kinase, ZAP70, SRK
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP14145c was selected from the Center region of ZAP70. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ZAP70
Gene ID: 7535
Primary Accession: P43403
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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