ZAP70 (Chronic Lymphocytic Leukemia Marker) (clone ZAP70/528 ), anti-human
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In stock
SKU
AC-AH12542
Catalog Number: AC-AH12542
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: ZAP70/528
Applications: IHC, IF, FC
Datasheet
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Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: ZAP70/528
Applications: IHC, IF, FC
Datasheet
Request Information
Background:
ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells.ĀControl of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well.ĀAnti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.
Other Names:
Tyrosine-protein kinase ZAP-70, 2.7.10.2, 70 kDa zeta-chain associated protein, Syk-related tyrosine kinase, ZAP70, SRK
Gene Name: ZAP70
Gene ID: 7535
Primary Accession: P43403
Other Accession: 7535, 234569
ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells.ĀControl of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well.ĀAnti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.
Other Names:
Tyrosine-protein kinase ZAP-70, 2.7.10.2, 70 kDa zeta-chain associated protein, Syk-related tyrosine kinase, ZAP70, SRK
Gene Name: ZAP70
Gene ID: 7535
Primary Accession: P43403
Other Accession: 7535, 234569
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