ZAP70 (clone 3D2A4), anti-human
€567.00
In stock
SKU
252649
Protein Family: Enzymes, Protein Kinases, Cellular Antigens
Pathway and Disease: Immune System
Description:
ZAP70 (Zeta-chain associated protein kinase) is a 70 kDa member of the SYK tyrosine kinase family. It plays a central role in lymphocyte activation and development, implicated in several immune disorders. ZAP70 controls TCR (T-cell antigen receptor)-linked signal transduction pathways. Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the ZAP70 gene. ZAP70 is also expressed in several types of B-cell neoplasm and is easily detected by immunohistochemistry, providing a useful prognostic marker in patients with chronic lymphocytic leukaemia.
Alternate Names: Tyrosine-protein kinase ZAP-70, 70 kDa zeta-chain associated protein, Syk-related tyrosine kinase, SRK, ZAP70
Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000
Accession No.: P43403
Antigen: Purified recombinant fragment of human ZAP70 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Immune System
Description:
ZAP70 (Zeta-chain associated protein kinase) is a 70 kDa member of the SYK tyrosine kinase family. It plays a central role in lymphocyte activation and development, implicated in several immune disorders. ZAP70 controls TCR (T-cell antigen receptor)-linked signal transduction pathways. Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the ZAP70 gene. ZAP70 is also expressed in several types of B-cell neoplasm and is easily detected by immunohistochemistry, providing a useful prognostic marker in patients with chronic lymphocytic leukaemia.
Alternate Names: Tyrosine-protein kinase ZAP-70, 70 kDa zeta-chain associated protein, Syk-related tyrosine kinase, SRK, ZAP70
Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000
Accession No.: P43403
Antigen: Purified recombinant fragment of human ZAP70 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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