ZBTB33 antibody (clone 2B2), anti-human
€435.00
In stock
SKU
AC-AT4570a
Catalog Number: AC-AT4570a
Size: 50 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF, E
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Size: 50 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF, E
Request Information AC-AT4570a">Request Information
Background:
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
Other Names:
Transcriptional regulator Kaiso, Zinc finger and BTB domain-containing protein 33, ZBTB33, KAISO, ZNF348
Antigen Type:
Recombinant Protein
Gene Name: ZBTB33
Gene ID: 10009
NCBI Accession: NP_001171671.1;NP_006768.1
Primary Accession: Q86T24
Other Accession: BC042753
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
Other Names:
Transcriptional regulator Kaiso, Zinc finger and BTB domain-containing protein 33, ZBTB33, KAISO, ZNF348
Antigen Type:
Recombinant Protein
Gene Name: ZBTB33
Gene ID: 10009
NCBI Accession: NP_001171671.1;NP_006768.1
Primary Accession: Q86T24
Other Accession: BC042753
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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