ZBTB7B (clone 7C12), anti-human
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In stock
SKU
BT-MCA3140
Catalog Number: BT-MCA3140
Size(s): 50μL, 100μL
Isotype: Mouse IgG1
Reactivity: human
Application(s): WB, IHC, ICC
Datasheet
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Size(s): 50μL, 100μL
Isotype: Mouse IgG1
Reactivity: human
Application(s): WB, IHC, ICC
Datasheet
Request Information
Background:
ZBTB7B is a transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. ZBTB7B is a transcriptional repressor of the collagen COL1A1 and COL1A2 genes. It may also function as a repressor of fibronectin and possibly other extracellular matrix genes.
Research Area: Epigenetics and nuclear signaling, Immunology
Synonyms: THPOK, ZFP67, ZBTB15, c-Krox, hcKrox, ZNF857B, DKFZp686G01254, ZBTB7B
Immunogen: Purified recombinant fragment of human ZBTB7B expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
Storage:
4°C|-20°C for long term storage
ZBTB7B is a transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. ZBTB7B is a transcriptional repressor of the collagen COL1A1 and COL1A2 genes. It may also function as a repressor of fibronectin and possibly other extracellular matrix genes.
Research Area: Epigenetics and nuclear signaling, Immunology
Synonyms: THPOK, ZFP67, ZBTB15, c-Krox, hcKrox, ZNF857B, DKFZp686G01254, ZBTB7B
Immunogen: Purified recombinant fragment of human ZBTB7B expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
Storage:
4°C|-20°C for long term storage
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