ZNF622 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP1952a
Background:
ZNF622 interacts with murine Melk and with itself when expressed in 293T cells. ZNF622 was phosphorylated by Melk both in vitro and in vivo. When expressed alone, ZNF622 exhibited cytosolic and nuclear localization; however, coexpression of ZNF622 with Melk resulted in nuclear localization of ZNF622. ZNF622 also interacts with the transcription factor BMYB in a yeast 2-hybrid assay and coimmunoprecipitated with BMYB when expressed in 293T cells. ZNF622 enhancs the transcriptional activity of BMYB on a reporter plasmid in a dose-dependent manner, and coexpression of ZNF622 and BMYB in 293T cells caused accumulation of both proteins in the nucleus. Constitutive expression of ZNF622 in retinoic acid-treated neuroblastoma cells or 293T cells induced apoptosis, but coexpression of ZNF622 with BMYB inhibited this apoptosis.
Other Names:
Zinc finger protein 622, Zinc finger-like protein 9, ZNF622, ZPR9
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1952a was selected from the N-term region of human ZNF622. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ZNF622 {ECO:0000303|PubMed:32669547, ECO:0000312|HGNC:HGNC:30958}
Gene ID: 90441
Primary Accession: Q969S3
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
ZNF622 interacts with murine Melk and with itself when expressed in 293T cells. ZNF622 was phosphorylated by Melk both in vitro and in vivo. When expressed alone, ZNF622 exhibited cytosolic and nuclear localization; however, coexpression of ZNF622 with Melk resulted in nuclear localization of ZNF622. ZNF622 also interacts with the transcription factor BMYB in a yeast 2-hybrid assay and coimmunoprecipitated with BMYB when expressed in 293T cells. ZNF622 enhancs the transcriptional activity of BMYB on a reporter plasmid in a dose-dependent manner, and coexpression of ZNF622 and BMYB in 293T cells caused accumulation of both proteins in the nucleus. Constitutive expression of ZNF622 in retinoic acid-treated neuroblastoma cells or 293T cells induced apoptosis, but coexpression of ZNF622 with BMYB inhibited this apoptosis.
Other Names:
Zinc finger protein 622, Zinc finger-like protein 9, ZNF622, ZPR9
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1952a was selected from the N-term region of human ZNF622. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ZNF622 {ECO:0000303|PubMed:32669547, ECO:0000312|HGNC:HGNC:30958}
Gene ID: 90441
Primary Accession: Q969S3
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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