GRK 6 polyclonal, anti-human, mouse, rat
€470.00
In stock
SKU
AC-AP70254
Background:
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
Other Names:
GRK6; GPRK6; G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK6
Antigen Type: synthetic peptide
Antigen Type: GRK6
Gene ID: 2870
Primary Accession: P43250
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
Other Names:
GRK6; GPRK6; G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK6
Antigen Type: synthetic peptide
Antigen Type: GRK6
Gene ID: 2870
Primary Accession: P43250
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