ZYX antibody (clone 2C10-4A7), anti-human
€435.00
In stock
SKU
AC-AT4653a
Catalog Number: AC-AT4653a
Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, IF, IP, E
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Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, IF, IP, E
Request Information AC-AT4653a">Request Information
Background:
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.
Other Names:
Zyxin, Zyxin-2, ZYX
Antigen Type:
Recombinant Protein
Gene Name: ZYX
Gene ID: 7791
NCBI Accession: NP_001010972.1;NP_003452.1
Primary Accession: Q15942
Other Accession: BC008743
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.
Other Names:
Zyxin, Zyxin-2, ZYX
Antigen Type:
Recombinant Protein
Gene Name: ZYX
Gene ID: 7791
NCBI Accession: NP_001010972.1;NP_003452.1
Primary Accession: Q15942
Other Accession: BC008743
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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