14-3-3γ polyclonal, anti-human, mouse, rat

Background:
14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 b, g, e, z, h, q and s. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins, by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity, and facilitation of protein modification. Loss of expression contributes to a vast array of pathogenic cellular activities.

Alternative Name:
KCIP-1, YWHAG, 14 3 3 gamma, 14 3 3 protein gamma, 14 3 3 protein gamma subtype, 14 3 3gamma, 14-3-3 protein gamma, 1433G, 3 monooxygenase/tryptophan 5 monooxgenase activation protein gamma polypeptide, KCIP 1, KCIP-1, KCIP1, N-terminally processed, Protein kinase C inhibitor protein 1, Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein gamma polypeptide, Ywhag,

Application Dilution:
WB:1:1,000-1:2,000
FC:1:10-1:50

Specificity: 14-3-3γ polyclonal antibody detects endogenous levels of 14-3-3γ protein.

Immunogen:
recombinant protein

MW: 28 kDa

Swiss-Prot: P61981(Human) P61982(Mouse) P61983(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.