8ODP polyclonal antibody, anti-human, mouse, rat

Background:
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates| such as 8-oxo-dGTP| 8-oxo-dATP| 2-hydroxy-dATP| and 2-hydroxy rATP| to monophosphates| thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm| with some in the mitochondria| suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants| some of which encode distinct isoforms| have been identified. Additional variants have been observed| but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional| longer is

Research Area: Epigenetics and nuclear signaling

Synonyms: 7, 8-dihydro-8-oxoguanine triphosphatase (EC 3.6.1.55, 2-hydroxy-dATP diphosphatase, EC 3.6.1.56, 8-oxo-dGTPase, Nucleoside diphosphate-linked moiety X motif 1, Nudix motif 1)

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year