BARD1 Antibody (N-term) Blocking peptide
€363.00
In stock
SKU
AC-BP10664a
Background:
BARD1 is a protein which interacts with theN-terminal region of BRCA1. In addition to its ability to bindBRCA1 in vivo and in vitro, it shares homology with the 2 mostconserved regions of BRCA1: the N-terminal RING motif and theC-terminal BRCT domain. The RING motif is a cysteine-rich sequencefound in a variety of proteins that regulate cell growth, includingthe products of tumor suppressor genes and dominant protooncogenes.This protein also contains 3 tandem ankyrin repeats. TheBARD1/BRCA1 interaction is disrupted by tumorigenic amino acidsubstitutions in BRCA1, implying that the formation of a stablecomplex between these proteins may be an essential aspect of BRCA1tumor suppression. This protein may be the target of oncogenicmutations in breast or ovarian cancer.
Other Names:
BRCA1-associated RING domain protein 1, BARD-1, 632-, BARD1
Gene Name: BARD1
Gene ID: 580
Primary Accession: Q99728
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
BARD1 is a protein which interacts with theN-terminal region of BRCA1. In addition to its ability to bindBRCA1 in vivo and in vitro, it shares homology with the 2 mostconserved regions of BRCA1: the N-terminal RING motif and theC-terminal BRCT domain. The RING motif is a cysteine-rich sequencefound in a variety of proteins that regulate cell growth, includingthe products of tumor suppressor genes and dominant protooncogenes.This protein also contains 3 tandem ankyrin repeats. TheBARD1/BRCA1 interaction is disrupted by tumorigenic amino acidsubstitutions in BRCA1, implying that the formation of a stablecomplex between these proteins may be an essential aspect of BRCA1tumor suppression. This protein may be the target of oncogenicmutations in breast or ovarian cancer.
Other Names:
BRCA1-associated RING domain protein 1, BARD-1, 632-, BARD1
Gene Name: BARD1
Gene ID: 580
Primary Accession: Q99728
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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