C4B Antibody (Center) Blocking peptide
€363.00
In stock
SKU
AC-BP13985c
Background:
This gene encodes the basic form of complement factor 4,part of the classical activation pathway. The protein is expressedas a single chain precursor which is proteolytically cleaved into atrimer of alpha, beta, and gamma chains prior to secretion. Thetrimer provides a surface for interaction between theantigen-antibody complex and other complement components. The alphachain may be cleaved to release C4 anaphylatoxin, a mediator oflocal inflammation. Deficiency of this protein is associated withsystemic lupus erythematosus. This gene localizes to the majorhistocompatibility complex (MHC) class III region on chromosome 6.Varying haplotypes of this gene cluster exist, such thatindividuals may have 1, 2, or 3 copies of this gene. In addition,this gene exists as a long form and a short form due to thepresence or absence of a 6.4 kb endogenous HERV-K retrovirus inintron 9.
Other Names:
Complement C4-A, Acidic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, Complement C4 beta chain, Complement C4-A alpha chain, C4a anaphylatoxin, C4b-A, C4d-A, Complement C4 gamma chain, C4A, CO4, CPAMD2
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13985c was selected from the Center region of C4B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: C4A
Gene ID: 720;721
Primary Accession: P0C0L4
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes the basic form of complement factor 4,part of the classical activation pathway. The protein is expressedas a single chain precursor which is proteolytically cleaved into atrimer of alpha, beta, and gamma chains prior to secretion. Thetrimer provides a surface for interaction between theantigen-antibody complex and other complement components. The alphachain may be cleaved to release C4 anaphylatoxin, a mediator oflocal inflammation. Deficiency of this protein is associated withsystemic lupus erythematosus. This gene localizes to the majorhistocompatibility complex (MHC) class III region on chromosome 6.Varying haplotypes of this gene cluster exist, such thatindividuals may have 1, 2, or 3 copies of this gene. In addition,this gene exists as a long form and a short form due to thepresence or absence of a 6.4 kb endogenous HERV-K retrovirus inintron 9.
Other Names:
Complement C4-A, Acidic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, Complement C4 beta chain, Complement C4-A alpha chain, C4a anaphylatoxin, C4b-A, C4d-A, Complement C4 gamma chain, C4A, CO4, CPAMD2
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13985c was selected from the Center region of C4B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: C4A
Gene ID: 720;721
Primary Accession: P0C0L4
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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