CCR10 Antibody (N-term) Blocking peptide
€363.00
In stock
SKU
AC-BP13744a
Background:
Chemokines are a group of small (approximately 8 to 14kD), mostly basic, structurally related molecules that regulatecell trafficking of various types of leukocytes throughinteractions with a subset of 7-transmembrane, G protein-coupledreceptors. Chemokines also play fundamental roles in thedevelopment, homeostasis, and function of the immune system, andthey have effects on cells of the central nervous system as well ason endothelial cells involved in angiogenesis or angiostasis.Chemokines are divided into 2 major subfamilies, CXC and CC, basedon the arrangement of the first 2 of the 4 conserved cysteineresidues; the 2 cysteines are separated by a single amino acid inCXC chemokines and are adjacent in CC chemokines. CCR10 is thereceptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactionsare involved in T cell-mediated skin inflammation (Homey et al.,2002 [PubMed 11821900]).
Other Names:
C-C chemokine receptor type 10, C-C CKR-10, CC-CKR-10, CCR-10, G-protein coupled receptor 2, CCR10, GPR2
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13744a was selected from the N-term region of CCR10. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CCR10
Gene ID: 2826
Primary Accession: P46092
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Chemokines are a group of small (approximately 8 to 14kD), mostly basic, structurally related molecules that regulatecell trafficking of various types of leukocytes throughinteractions with a subset of 7-transmembrane, G protein-coupledreceptors. Chemokines also play fundamental roles in thedevelopment, homeostasis, and function of the immune system, andthey have effects on cells of the central nervous system as well ason endothelial cells involved in angiogenesis or angiostasis.Chemokines are divided into 2 major subfamilies, CXC and CC, basedon the arrangement of the first 2 of the 4 conserved cysteineresidues; the 2 cysteines are separated by a single amino acid inCXC chemokines and are adjacent in CC chemokines. CCR10 is thereceptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactionsare involved in T cell-mediated skin inflammation (Homey et al.,2002 [PubMed 11821900]).
Other Names:
C-C chemokine receptor type 10, C-C CKR-10, CC-CKR-10, CCR-10, G-protein coupled receptor 2, CCR10, GPR2
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13744a was selected from the N-term region of CCR10. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CCR10
Gene ID: 2826
Primary Accession: P46092
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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