CD95 (FAS) polyclonal, anti-mouse, rat

Protein Family: Cellular Antigens, Receptors and Channels

Pathway and Disease: Cancers, Cell Growth and Death, Immune System, Metabolic Disorders, Neurodegenerative Disorders, Signal Transduction, Signaling Molecules and Interaction

Description:
The FAS antigen (CD95) is a 40-50 kDa cell surface glycoprotein that belongs to the nerve growth factor/tumor necrosis factor (TNF) receptor family. FAS is a receptor for TNFSF6/FASL. The adaptor molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (asparte-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance in the antigen-stimulated suicide of mature T-cells or both. Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A), a childhood syndrome involving hemolytic anemia and thrombocytopenia.

Alternate Names: FAS, Apo-1, CD95, TNFR superfamily member, FasL receptor, Tumor necrosis factor receptor superfamily member 6, FASLG receptor, Apoptosis-mediating surface antigen FAS, Apo-1 antigen

Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Accession No.: Q63199

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of rat FAS.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.