CDK1 (phospho-T14) polyclonal, anti-human, mouse, rat

Background:
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Synonyms: CDC2, CDC28A, P34CDC2

Cellular Location: Cytoplasm Mitochondrion Nucleus centrosome cytoskeleton microtubule organizing center spindle

Immunogen:
A phospho specific peptide corresponding to residues surrounding T14 of human CDK1

Gene Symbol: Phospho-CDK1-T14

Gene ID: 983

Swiss prot: P06493

Calculated MW: 34kDa

Recommended dilution:
WB 1:500-1000, IF 1:50-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.