CDKL5 (STK9) polyclonal (C-term), anti-human
€0.00
In stock
SKU
AC-AP7244b
Catalog Number: AC-AP7244b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB3556
Applications: IHC-P, WB
Datasheet
Request Information
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB3556
Applications: IHC-P, WB
Datasheet
Request Information
Background:
Defects in STK9, a dual-specificity serine/threonine kinase, are a cause of atypical Rett syndrome. Rett syndrome is an X-linked dominant disease. It is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Patients appear to develop normally until 6 to 18 months of age, then gradually lose speech and purposeful hand movements and develop microcephaly, seizures, autism, ataxia, intermittent hyperventilation, and stereotypic hand movements. After initial regression, the condition stabilizes and patients usually survive into adulthood. Rett syndrome due to CDKL5-associated mutations is characterized by a severe early-onset phenotype and atypical features such as infantile spasms.
Other Names:
Cyclin-dependent kinase-like 5, Serine/threonine-protein kinase 9, CDKL5, STK9
Target/Specificity:
This CDKL5 (STK9) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 982-1012 amino acids from the C-terminal region of human CDKL5 (STK9).
Antigen Region:
982-1012
Antigen Type: Synthetic Peptide
Gene Name: CDKL5 (HGNC:11411)
Gene ID: 6792
Primary Accession: O76039
NCBI Accession: NP_001032420.1;NP_003150.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Defects in STK9, a dual-specificity serine/threonine kinase, are a cause of atypical Rett syndrome. Rett syndrome is an X-linked dominant disease. It is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Patients appear to develop normally until 6 to 18 months of age, then gradually lose speech and purposeful hand movements and develop microcephaly, seizures, autism, ataxia, intermittent hyperventilation, and stereotypic hand movements. After initial regression, the condition stabilizes and patients usually survive into adulthood. Rett syndrome due to CDKL5-associated mutations is characterized by a severe early-onset phenotype and atypical features such as infantile spasms.
Other Names:
Cyclin-dependent kinase-like 5, Serine/threonine-protein kinase 9, CDKL5, STK9
Target/Specificity:
This CDKL5 (STK9) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 982-1012 amino acids from the C-terminal region of human CDKL5 (STK9).
Antigen Region:
982-1012
Antigen Type: Synthetic Peptide
Gene Name: CDKL5 (HGNC:11411)
Gene ID: 6792
Primary Accession: O76039
NCBI Accession: NP_001032420.1;NP_003150.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
|---|
Write Your Own Review