CEP57 Polyclonal Antibody

Background:
This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Research Area: Signal transduction, Stem cells

Synonyms:
Centrosomal protein 57kDa, Centrosomal protein of 57 kDa, Cep57, Cep57 protein, CEP57, FGF2 interacting protein, FGF2-interacting protein, KIAA0092, MVA2, PIG8, Proliferation inducing protein 8, Testis specific protein 57, Testis-specific protein 57, Translokin, TSP57

Immunogen: Full length fusion protein

Swissprot: Q86XR8
Gene Accession: BC039711

Calculated MW: 57 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.4 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.