CLCN7 Polyclonal Antibody

Background:
The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood.

Research Area: Metabolism, Signal Transduction

Synonyms:
Chloride channel protein 7, CLC 7, ClC-7, ClC7, CLCN7, CLCN7, FLJ26686, FLJ39644, FLJ46423, H(+)/Cl(-) exchange transporter 7, OPTA2, OPTB4

Immunogen: Fusion protein of human CLCN7

Swissprot: P51798
Gene Accession: BC012737

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.56 mg/mL
Dilution: IHC 1:50-1:100, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.