CLCNKA polyclonal, anti-human, rat
€305.00
In stock
SKU
BS5665
Background:
CLC-KA is a kidney-specific chloride channel that mediates transepithelial chloride transport in the thin ascending limb of the Henle loop in the inner medulla. CLC-KA plays a crucial role in urine concentration. The gene encoding human CLC-KA maps to chromosome 1p36. Mutations in this gene may be associated with nephrogenic diabetes insipidus in those cases where mutations in the vasopressin V2 receptor and the AQP2 water channel are lacking. CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and in more distal nephron segments. The gene encoding human CLC-KB maps to chromosome 1p36. Mutations in this gene cause type III Barter’s syndrome which is characterized by renal salt-wasting and low blood pressure.
Alternative Name:
Chloride channel protein ClC-Ka, Chloride channel Ka, ClC-K1, CLC-KA, CLCKA
Application Dilution: WB: 1:500~1:1000
Specificity: CLCNKA polyclonal antibody detects endogenous levels of CLCNKA protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 626-671 of Human CLCNKA.
MW: ~ 75 kDa
Swis Prot.: P51800
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
CLC-KA is a kidney-specific chloride channel that mediates transepithelial chloride transport in the thin ascending limb of the Henle loop in the inner medulla. CLC-KA plays a crucial role in urine concentration. The gene encoding human CLC-KA maps to chromosome 1p36. Mutations in this gene may be associated with nephrogenic diabetes insipidus in those cases where mutations in the vasopressin V2 receptor and the AQP2 water channel are lacking. CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and in more distal nephron segments. The gene encoding human CLC-KB maps to chromosome 1p36. Mutations in this gene cause type III Barter’s syndrome which is characterized by renal salt-wasting and low blood pressure.
Alternative Name:
Chloride channel protein ClC-Ka, Chloride channel Ka, ClC-K1, CLC-KA, CLCKA
Application Dilution: WB: 1:500~1:1000
Specificity: CLCNKA polyclonal antibody detects endogenous levels of CLCNKA protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 626-671 of Human CLCNKA.
MW: ~ 75 kDa
Swis Prot.: P51800
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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