Cleaved-MMP-23 (Y79) polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS7054
Background:
Matrix metalloproteinases (MMPs) are highly homologous Zn2+ endopeptidases involved in extracellular matrix breakdown. MMP mediated extracellular remodeling occurs in normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, including arthritis and metastasis. MMP-23 exhibits sequence similarity with most MMPs, but displays a difference in domain structure. The MMP-23 protein contains prepro-, catalytic, cysteine-rich, Interleukin-1 receptor-related and proline-rich domains. Lacking a recognizable signal sequence, MMP-23 has a short prodomain. In addition, MMP-23 contains a single cysteine residue that can be part of the cysteine-switch mechanism operation for maintaining enzyme latency. MMP-23 is a membrane-anchored glycoprotein with type II topology. Subcellular localization is predominantly perinuclear.
Alternative Name:
Matrix metalloproteinase-23, MMP 23, Femalysin, MIFR-1, Matrix metalloproteinase-21, MMP-21, Matrix metalloproteinase-22, MMP-22, Matrix metalloproteinase-23, soluble form, MMP23A, MMP21, MMP23B, MMP21, MMP22, MMP23
Application Dilution: WB: 1:500~1:1000
Specificity: Cleaved-MMP-23 (Y79) polyclonal antibody detects endogenous levels of Cleaved-MMP-23 (37 kDa) protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 51-100 of Human MMP-23.
MW: ~ 37, 44 kDa
Swis Prot.: O75900
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Matrix metalloproteinases (MMPs) are highly homologous Zn2+ endopeptidases involved in extracellular matrix breakdown. MMP mediated extracellular remodeling occurs in normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, including arthritis and metastasis. MMP-23 exhibits sequence similarity with most MMPs, but displays a difference in domain structure. The MMP-23 protein contains prepro-, catalytic, cysteine-rich, Interleukin-1 receptor-related and proline-rich domains. Lacking a recognizable signal sequence, MMP-23 has a short prodomain. In addition, MMP-23 contains a single cysteine residue that can be part of the cysteine-switch mechanism operation for maintaining enzyme latency. MMP-23 is a membrane-anchored glycoprotein with type II topology. Subcellular localization is predominantly perinuclear.
Alternative Name:
Matrix metalloproteinase-23, MMP 23, Femalysin, MIFR-1, Matrix metalloproteinase-21, MMP-21, Matrix metalloproteinase-22, MMP-22, Matrix metalloproteinase-23, soluble form, MMP23A, MMP21, MMP23B, MMP21, MMP22, MMP23
Application Dilution: WB: 1:500~1:1000
Specificity: Cleaved-MMP-23 (Y79) polyclonal antibody detects endogenous levels of Cleaved-MMP-23 (37 kDa) protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 51-100 of Human MMP-23.
MW: ~ 37, 44 kDa
Swis Prot.: O75900
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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