COL18A1 Polyclonal Antibody

Background:
collagen type XVIII alpha 1 chain(COL18A1) Homo sapiens This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],

Alternative Names:
COL18A1, Collagen alpha-1(XVIII) chain

Immunogen: The antiserum was produced against synthesized peptide derived from human Collagen XVIII alpha1. AA range:801-850

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

GeneID: COL18A1

Storage: -20°C/1 year

NOTE: For Research Use Only