COL1A2 Polyclonal Antibody

Background:
This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Research Area: Cancer, Signal Transduction, Stem Cells

Synonyms:
Alpha 2 collagen type I, Alpha 2 type I collagen, Alpha 2 type I procollagen, Alpha 2(I) collagen, Alpha 2(I) procollagen, Alpha-2 type I collagen, CO1A2, COL1A2, Collagen alpha 2(I) chain, Collagen alpha-2(I) chain, Collagen I alpha 2 polypeptide, Collagen of skin tendon and bone alpha 2 chain, Collagen type I alpha 2, OI4, Osteogenesis imperfecta type IV, Type I procollagen

Immunogen: Recombinant protein of human COL1A2

Swissprot: P08123
Gene Accession: BC042586

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.1 mg/mL
Dilution: IHC 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-8787/sc-8786/sc-8785/sc-28655