Connexin-43 polyclonal, anti-human, mouse, rat

Protein Family: Receptors and Channels

Pathway and Disease: Cell Communication, Development and Behavior, Membrane Transport, Neurodegenerative Disorders

Description:
Connexin-43 (Gap junction alpha-1 protein, GJA1) forms connexons at cell gap junctions through which materials of low MW diffuse from one cell to a neighboring cell. Connexin-43 has a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Connexons are composed of a hexamer of connexins. Connexin-43 is expressed in the heart and fetal cochlear. Defects in Connexin-43 are the cause of autosomal dominant oculodentodigital dysplasia (ODDD), a serious condition of cranofacial anomalies, ocular defects and sometimes deafness and cardiac abnormalities.

Alternate Names: Connexin-43, Gap junction alpha-1 protein, Cx43, Gap junction 43 kDa heart protein, GJA1, GJAL

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P17302

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human connexin-43.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.