Connexin-43 polyclonal, anti-humna, mouse, rat

Protein Family: Receptors and Channels

Pathway and Disease: Membrane Transport, Nervous and Sensory Systems, Neurodegenerative Disorders

Description:
Gap junction alpha-1 protein (connexin-43) is a transmembrane channel that, together with other connexins, forms a gap junction. Gap junctions allow low MW materials to flow from one cell to a neighboring cell. Defects in connexin-43 are the cause of autosomal dominant oculodentodigital dysplasia (ODDD), also known as oculodentoosseous dysplasia. ODDD is a highly penetrant syndrome presenting with craniofacial (ocular, nasal, dental) and limb dysmorphisms, spastic paraplegia, and neurodegeneration.

Alternate Names: Connexin-43, Gap junction alpha-1 protein, Cx43, Gap junction 43 kDa heart protein, GJA1, GJAL

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; ICC: 1:100-1:500

Accession No.: P17302

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human connexin-43.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 50% glycerol with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatograph

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.