CPXM2 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61150
Background:
Members of the M14 metallocarboxypeptidase protein family serve many diverse functions and are divided into three subfamilies based on structure, function and amino acid sequence similarity. Belonging to the N/E subfamily, CPXM2 (Inactive carboxypeptidase-like protein X2) is a 756 amino acid protein that contains a F5/8 type C domain and is secreted. Most members of the N/E subfamily contain several domains, including an active carboxypeptidase domain and signal peptide and are thought to function mostly in mediating protein-protein interactions and/or protein-membrane interactions, thereby targeting the protein to specific locations within the secretory pathway. CPXM2 is a unique member of this subfamily in that it does not appear to exhibit any enzymatic activity due to lack of several active-site residues that are present in the catalytic domain of other members of the N/E subfamily. Expression of the closely related protein CPXM is regulated during osteoclastogenesis, suggesting that CPXM may play a role in osteoclast differentiation.
Alternative Name:
Inactive carboxypeptidase-like protein X2, CPXM2
Application Dilution: WB: 1:500~1:1000
Specificity: CPXM2 polyclonal antibody detects endogenous levels of CPXM2 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human CPXM2.
MW: ~ 86 kDa
Swis Prot.: Q8N436
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Members of the M14 metallocarboxypeptidase protein family serve many diverse functions and are divided into three subfamilies based on structure, function and amino acid sequence similarity. Belonging to the N/E subfamily, CPXM2 (Inactive carboxypeptidase-like protein X2) is a 756 amino acid protein that contains a F5/8 type C domain and is secreted. Most members of the N/E subfamily contain several domains, including an active carboxypeptidase domain and signal peptide and are thought to function mostly in mediating protein-protein interactions and/or protein-membrane interactions, thereby targeting the protein to specific locations within the secretory pathway. CPXM2 is a unique member of this subfamily in that it does not appear to exhibit any enzymatic activity due to lack of several active-site residues that are present in the catalytic domain of other members of the N/E subfamily. Expression of the closely related protein CPXM is regulated during osteoclastogenesis, suggesting that CPXM may play a role in osteoclast differentiation.
Alternative Name:
Inactive carboxypeptidase-like protein X2, CPXM2
Application Dilution: WB: 1:500~1:1000
Specificity: CPXM2 polyclonal antibody detects endogenous levels of CPXM2 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human CPXM2.
MW: ~ 86 kDa
Swis Prot.: Q8N436
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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