CYFIP1 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60773
Background:
Fragile X syndrome is the most frequent form of inherited mental retardation and is a result of transcriptional silencing of the FMR1 gene on the X chromosome. The FMR1 protein (also designated FMRP) is an RNA-binding protein that associates with polyribosomes and is a likely component of a messenger ribonuclear protein (mRNP) particle. FMR1 can also interact with two fragile X syndrome related factors, FXR1 (also designated FXR1P) and FXR2 (also designated FXR2P). These proteins form heterodimers through their N-terminal coiled-coiled domains. CYFIP1 and CYFIP2 (also known as cytoplasmic FMRP interacting proteins 1 and 2, respectively, and as Sra-1 in mouse) both interact with FMR1 but CYFIP2 also reacts with FXR1 and FXR2. CYFIP1 and CYFIP2 bind GTP-bound Rac1 to release FMRP in its active state, which is thought to regulate mRNA translation of neural cytoskeletal proteins. A loss of CYFIP1 and CYFIP2 leads to mutant neurons with defective axonal growth and motor function.
Alternative Name:
ytoplasmic FMR1-interacting protein 1, Specifically Rac1-associated protein 1, Sra-1, p140sra-1, CYFIP1, KIAA0068
Application Dilution: WB: 1:500~1:1000
Specificity: CYFIP1 polyclonal antibody detects endogenous levels of CYFIP1 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human CYFIP1
MW: ~ 145 kDa
Swis Prot.: Q7L576
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Fragile X syndrome is the most frequent form of inherited mental retardation and is a result of transcriptional silencing of the FMR1 gene on the X chromosome. The FMR1 protein (also designated FMRP) is an RNA-binding protein that associates with polyribosomes and is a likely component of a messenger ribonuclear protein (mRNP) particle. FMR1 can also interact with two fragile X syndrome related factors, FXR1 (also designated FXR1P) and FXR2 (also designated FXR2P). These proteins form heterodimers through their N-terminal coiled-coiled domains. CYFIP1 and CYFIP2 (also known as cytoplasmic FMRP interacting proteins 1 and 2, respectively, and as Sra-1 in mouse) both interact with FMR1 but CYFIP2 also reacts with FXR1 and FXR2. CYFIP1 and CYFIP2 bind GTP-bound Rac1 to release FMRP in its active state, which is thought to regulate mRNA translation of neural cytoskeletal proteins. A loss of CYFIP1 and CYFIP2 leads to mutant neurons with defective axonal growth and motor function.
Alternative Name:
ytoplasmic FMR1-interacting protein 1, Specifically Rac1-associated protein 1, Sra-1, p140sra-1, CYFIP1, KIAA0068
Application Dilution: WB: 1:500~1:1000
Specificity: CYFIP1 polyclonal antibody detects endogenous levels of CYFIP1 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human CYFIP1
MW: ~ 145 kDa
Swis Prot.: Q7L576
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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