DCLK2 Blocking Peptide (N-term)
€363.00
In stock
SKU
AC-BP19971A
Background:
This gene encodes a member of the protein kinasesuperfamily and the doublecortin family. The protein encoded bythis gene contains two N-terminal doublecortin domains, which bindmicrotubules and regulate microtubule polymerization, a C-terminalserine/threonine protein kinase domain, which shows substantialhomology to Ca2+/calmodulin-dependent protein kinase, and aserine/proline-rich domain in between the doublecortin and theprotein kinase domains, which mediates multiple protein-proteininteractions. The microtubule-polymerizing activity of the encodedprotein is independent of its protein kinase activity. Mousestudies show that the DCX gene, another family member, and thisgene share function in the establishment of hippocampalorganization and that their absence results in a severe epilepticphenotype and lethality, as described in human patients withlissencephaly. Multiple alternatively spliced transcript variantshave been identified.
Other Names:
Serine/threonine-protein kinase DCLK2, CaMK-like CREB regulatory kinase 2, CL2, CLICK-II, CLICK2, Doublecortin domain-containing protein 3B, Doublecortin-like and CAM kinase-like 2, Doublecortin-like kinase 2, DCLK2, DCAMKL2, DCDC3B, DCK2
Target/Specificity:
The synthetic peptide sequence is selected from aa 182-196 of HUMAN DCLK2
Gene Name: DCLK2
Gene ID: 166614
Primary Accession: Q8N568
Other Accession: NP_001035351.3
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a member of the protein kinasesuperfamily and the doublecortin family. The protein encoded bythis gene contains two N-terminal doublecortin domains, which bindmicrotubules and regulate microtubule polymerization, a C-terminalserine/threonine protein kinase domain, which shows substantialhomology to Ca2+/calmodulin-dependent protein kinase, and aserine/proline-rich domain in between the doublecortin and theprotein kinase domains, which mediates multiple protein-proteininteractions. The microtubule-polymerizing activity of the encodedprotein is independent of its protein kinase activity. Mousestudies show that the DCX gene, another family member, and thisgene share function in the establishment of hippocampalorganization and that their absence results in a severe epilepticphenotype and lethality, as described in human patients withlissencephaly. Multiple alternatively spliced transcript variantshave been identified.
Other Names:
Serine/threonine-protein kinase DCLK2, CaMK-like CREB regulatory kinase 2, CL2, CLICK-II, CLICK2, Doublecortin domain-containing protein 3B, Doublecortin-like and CAM kinase-like 2, Doublecortin-like kinase 2, DCLK2, DCAMKL2, DCDC3B, DCK2
Target/Specificity:
The synthetic peptide sequence is selected from aa 182-196 of HUMAN DCLK2
Gene Name: DCLK2
Gene ID: 166614
Primary Accession: Q8N568
Other Accession: NP_001035351.3
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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