DIAPH1 polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS7851
Background:
Dia 1 (also designated p140mDia) and Dia 2 (also designated p134mDia 2), mammalian homologs of Drosophila Diaphanous, belong to a family of formin-homology (FH) proteins, which are characterized by having tandemly aligned FH1 and FH2 domains in their carboxy terminal regions. The amino terminus of inactivated Dia 1 binds to the FH1 and FH2 domains, and is activated when GTP-bound Rho disrupts the intramolecular interaction of Dia 1 and converts it to an open conformation. Once activated, Dia 1 co-localizes with profilin and RhoA in dynamic plasma-membrane structures, and induces the formation of stress fibers in conjunction with the ROCK mediated signaling pathway. However, Dia 1 and ROCK activities antagonize each other in order to determine the thickness and density of the stress fibers formed. Dia 1 has also been implicated as the gene responsible for non-syndromic deafness.
Alternative Name:
DIAPH1, deafness, autosomal dominant 1, DFNA1, DIA1, DIAP1, DIAP1_HUMAN, DIAPH1, Diaphanous homolog 1 (Drosophila), diaphanous homolog 1, Diaphanous related formin 1, Diaphanous-related formin-1, DRF1, FLJ25265, hDIA1, LFHL1, low frequency hearing loss 1, p140DIA, Protein diaphanous homolog 1,
Application Dilution: WB: 1:500 - 1:2000, IF: 1:50 - 1:100
Specificity: DIAPH1 polyclonal antibody detects endogenous levels of DIAPH1 protein.
Immunogen:
Recombinant full length Human DIAPH1.
MW: ~ 141, 150 kDa
Swis Prot.: O60610
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Dia 1 (also designated p140mDia) and Dia 2 (also designated p134mDia 2), mammalian homologs of Drosophila Diaphanous, belong to a family of formin-homology (FH) proteins, which are characterized by having tandemly aligned FH1 and FH2 domains in their carboxy terminal regions. The amino terminus of inactivated Dia 1 binds to the FH1 and FH2 domains, and is activated when GTP-bound Rho disrupts the intramolecular interaction of Dia 1 and converts it to an open conformation. Once activated, Dia 1 co-localizes with profilin and RhoA in dynamic plasma-membrane structures, and induces the formation of stress fibers in conjunction with the ROCK mediated signaling pathway. However, Dia 1 and ROCK activities antagonize each other in order to determine the thickness and density of the stress fibers formed. Dia 1 has also been implicated as the gene responsible for non-syndromic deafness.
Alternative Name:
DIAPH1, deafness, autosomal dominant 1, DFNA1, DIA1, DIAP1, DIAP1_HUMAN, DIAPH1, Diaphanous homolog 1 (Drosophila), diaphanous homolog 1, Diaphanous related formin 1, Diaphanous-related formin-1, DRF1, FLJ25265, hDIA1, LFHL1, low frequency hearing loss 1, p140DIA, Protein diaphanous homolog 1,
Application Dilution: WB: 1:500 - 1:2000, IF: 1:50 - 1:100
Specificity: DIAPH1 polyclonal antibody detects endogenous levels of DIAPH1 protein.
Immunogen:
Recombinant full length Human DIAPH1.
MW: ~ 141, 150 kDa
Swis Prot.: O60610
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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