DMGDH Polyclonal Antibody

Background:
This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum. Alternative splicing results in multiple transcript variants.

Research Area: Metabolism, Neuroscience, Signal Transduction

Synonyms:
Dimethylglycine dehydrogenase, Dimethylglycine dehydrogenase, mitochondrial, Dmgdh, M2GD, ME2GLYDH, mitochondrial

Immunogen: Synthetic peptide of human DMGDH

Swissprot: Q9UI17
Gene Accession: NP037523

Calculated MW: 97 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 2.1 mg/mL
Dilution: WB 1:500-1:2000, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.