DOK1 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP7690a
Background:
DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. DOK2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
Other Names:
Docking protein 1, Downstream of tyrosine kinase 1, p62(dok), pp62, DOK1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7690a was selected from the N-term region of human DOK1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: DOK1
Gene ID: 1796
Primary Accession: Q99704
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. DOK2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
Other Names:
Docking protein 1, Downstream of tyrosine kinase 1, p62(dok), pp62, DOK1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7690a was selected from the N-term region of human DOK1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: DOK1
Gene ID: 1796
Primary Accession: Q99704
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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