DUSP12 Antibody (Center) Blocking Peptide
€363.00
In stock
SKU
AC-BP16903c
Background:
The protein encoded by this gene is a member of the dualspecificity protein phosphatase subfamily. These phosphatasesinactivate their target kinases by dephosphorylating both thephosphoserine/threonine and phosphotyrosine residues. Theynegatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associatedwith cellular proliferation and differentiation. Different membersof the family of dual specificity phosphatases show distinctsubstrate specificities for various MAP kinases, different tissuedistribution and subcellular localization, and different modes ofinducibility of their expression by extracellular stimuli. Thisgene product is the human ortholog of the Saccharomyces cerevisiaeYVH1 protein tyrosine phosphatase. It is localized predominantly inthe nucleus, and is novel in that it contains, and is regulated bya zinc finger domain.
Other Names:
Dual specificity protein phosphatase 12, Dual specificity tyrosine phosphatase YVH1, DUSP12
Gene Name: DUSP12
Gene ID: 11266
Primary Accession: Q9UNI6
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein encoded by this gene is a member of the dualspecificity protein phosphatase subfamily. These phosphatasesinactivate their target kinases by dephosphorylating both thephosphoserine/threonine and phosphotyrosine residues. Theynegatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associatedwith cellular proliferation and differentiation. Different membersof the family of dual specificity phosphatases show distinctsubstrate specificities for various MAP kinases, different tissuedistribution and subcellular localization, and different modes ofinducibility of their expression by extracellular stimuli. Thisgene product is the human ortholog of the Saccharomyces cerevisiaeYVH1 protein tyrosine phosphatase. It is localized predominantly inthe nucleus, and is novel in that it contains, and is regulated bya zinc finger domain.
Other Names:
Dual specificity protein phosphatase 12, Dual specificity tyrosine phosphatase YVH1, DUSP12
Gene Name: DUSP12
Gene ID: 11266
Primary Accession: Q9UNI6
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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