Dynamin-1 (phospho-S774) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4228
Background:
Members of the Dynamin family, including Dynamin I and Dynamin II, are GTPase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin I is localized to the central nervous system, while Dynamin II exhibits ubiquitous distribution with highest expression in testis. Both Dynamin proteins contain SH3 and proline-rich domains that mediate interactions between the Dynamins and effectors of their GTPase activity. The interactions with these effectors, which include microtubules, acidic phospholipids and SH3 domain-containing proteins, are required for rapid endocytosis. Dynamin I appears to be recruited to Clathrin coated pits by SH3 domain interaction with Amphiphysin, a protein highly expressed in brain.
Alternative Name:
Dynamin 1, Dynamin1, DNM1, DNM, Dynamin I, Dynamin-I, DynaminI
Application Dilution: WB: 1:500~1:1000
Specificity: p-Dynamin-1 (S774) polyclonal antibody detects endogenous levels of Dynamin-1 protein when phosphorylated at Ser774.
Immunogen:
Synthetic phosphopeptide derived from human Dynamin-1 around the phosphorylation site of Serine 774.
MW: ~ 98 kDa
Swis Prot.: Q05193
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Members of the Dynamin family, including Dynamin I and Dynamin II, are GTPase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin I is localized to the central nervous system, while Dynamin II exhibits ubiquitous distribution with highest expression in testis. Both Dynamin proteins contain SH3 and proline-rich domains that mediate interactions between the Dynamins and effectors of their GTPase activity. The interactions with these effectors, which include microtubules, acidic phospholipids and SH3 domain-containing proteins, are required for rapid endocytosis. Dynamin I appears to be recruited to Clathrin coated pits by SH3 domain interaction with Amphiphysin, a protein highly expressed in brain.
Alternative Name:
Dynamin 1, Dynamin1, DNM1, DNM, Dynamin I, Dynamin-I, DynaminI
Application Dilution: WB: 1:500~1:1000
Specificity: p-Dynamin-1 (S774) polyclonal antibody detects endogenous levels of Dynamin-1 protein when phosphorylated at Ser774.
Immunogen:
Synthetic phosphopeptide derived from human Dynamin-1 around the phosphorylation site of Serine 774.
MW: ~ 98 kDa
Swis Prot.: Q05193
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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