Dystrophin polyclonal, anti-human, mouse, rat

Background:
Dystrophin-glycoprotein complex (DGC) connects the F-Actin cytoskeleton on the inner surface of muscle fibers to the surrounding extracellular matrix, through the cell membrane interface. A deficiency in this protein contributes to Duchenne (DMD) and Becker (BMD) muscular dystrophies. The human dystrophin gene measures 2.4 megabases, has more than 80 exons, produces a 14 kb mRNA and contains at least eight independent tissue-specific promoters and two poly A sites. The dystrophin mRNA can undergo differential splicing and produce a range of transcripts that encode a large set of proteins. Dystrophin represents approximately 0.002% of total striated muscle protein and localizes to triadic junctions in skeletal muscle, where it is thought to influence calcium ion homeostasis and force transmission.

Alternative Name:
DMD, BMD, CMD3B, DMD, DMD, Duchenne muscular dystrophy protein, Dystrophin, Muscular dystrophy Duchenne and Becker types,

Application Dilution:
WB:1:1,000
IHC:1:50-1:200

Specificity: Dystrophin polyclonal antibody detects endogenous levels of Dystrophin protein.

Immunogen:
recombinant protein

MW: 427 kDa

Swiss-Prot: P11532(Human) P11531(Mouse) P11530(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.