E2F1 Antibody (Center) Blocking peptide
€363.00
In stock
SKU
AC-BP7593d
Background:
E2F1 is a member of the E2Ffamily of transcription factors. The E2F family plays a crucialrole in the control of cell cycle and action of tumor suppressorproteins and is also a target of the transforming proteins of smallDNA tumor viruses. The E2F proteins contain several evolutionallyconserved domains found in most members of the family. Thesedomains include a DNA binding domain, a dimerization domain whichdetermines interaction with the differentiation regulatedtranscription factor proteins (DP), a transactivation domainenriched in acidic amino acids, and a tumor suppressor proteinassociation domain which is embedded within the transactivationdomain. This protein and another 2 members, E2F2 and E2F3, have anadditional cyclin binding domain. This protein binds preferentiallyto retinoblastoma protein pRB in a cell-cycle dependent manner. Itcan mediate both cell proliferation and p53-dependent/independentapoptosis.
Other Names:
Transcription factor E2F1, E2F-1, PBR3, Retinoblastoma-associated protein 1, RBAP-1, Retinoblastoma-binding protein 3, RBBP-3, pRB-binding protein E2F-1, E2F1, RBBP3
Gene Name: E2F1 {ECO:0000303|PubMed:8964493, ECO:0000312|HGNC:HGNC:3113}
Gene ID: 1869
Primary Accession: Q01094
Other Accession: NP_005216
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
E2F1 is a member of the E2Ffamily of transcription factors. The E2F family plays a crucialrole in the control of cell cycle and action of tumor suppressorproteins and is also a target of the transforming proteins of smallDNA tumor viruses. The E2F proteins contain several evolutionallyconserved domains found in most members of the family. Thesedomains include a DNA binding domain, a dimerization domain whichdetermines interaction with the differentiation regulatedtranscription factor proteins (DP), a transactivation domainenriched in acidic amino acids, and a tumor suppressor proteinassociation domain which is embedded within the transactivationdomain. This protein and another 2 members, E2F2 and E2F3, have anadditional cyclin binding domain. This protein binds preferentiallyto retinoblastoma protein pRB in a cell-cycle dependent manner. Itcan mediate both cell proliferation and p53-dependent/independentapoptosis.
Other Names:
Transcription factor E2F1, E2F-1, PBR3, Retinoblastoma-associated protein 1, RBAP-1, Retinoblastoma-binding protein 3, RBBP-3, pRB-binding protein E2F-1, E2F1, RBBP3
Gene Name: E2F1 {ECO:0000303|PubMed:8964493, ECO:0000312|HGNC:HGNC:3113}
Gene ID: 1869
Primary Accession: Q01094
Other Accession: NP_005216
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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