ENC1 Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP17107b
Background:
DNA damage and/or hyperproliferative signals activatewildtype p53 tumor suppressor protein (TP53; MIM 191170), inducingcell cycle arrest or apoptosis. Mutations that inactivate p53 occurin 50% of all tumors. Polyak et al. (1997) [PubMed 9305847] usedserial analysis of gene expression (SAGE) to evaluate cellular mRNAlevels in a colorectal cancer cell line transfected with p53. Of7,202 transcripts identified, only 14 were expressed at levels morethan 10-fold higher in p53-expressing cells than in control cells.Polyak et al. (1997) [PubMed 9305847] termed these genes'p53-induced genes,' or PIGs, several of which were predicted toencode redox-controlling proteins. They noted that reactive oxygenspecies (ROS) are potent inducers of apoptosis. Flow cytometricanalysis showed that p53 expression induces ROS production, whichincreases as apoptosis progresses under some conditions. Theauthors stated that the PIG10 gene, also called ENC1, encodes anactin-binding protein.
Other Names:
Ectoderm-neural cortex protein 1, ENC-1, Kelch-like protein 37, Nuclear matrix protein NRP/B, p53-induced gene 10 protein, ENC1, KLHL37, NRPB, PIG10
Gene Name: ENC1
Gene ID: 8507
Primary Accession: O14682
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
DNA damage and/or hyperproliferative signals activatewildtype p53 tumor suppressor protein (TP53; MIM 191170), inducingcell cycle arrest or apoptosis. Mutations that inactivate p53 occurin 50% of all tumors. Polyak et al. (1997) [PubMed 9305847] usedserial analysis of gene expression (SAGE) to evaluate cellular mRNAlevels in a colorectal cancer cell line transfected with p53. Of7,202 transcripts identified, only 14 were expressed at levels morethan 10-fold higher in p53-expressing cells than in control cells.Polyak et al. (1997) [PubMed 9305847] termed these genes'p53-induced genes,' or PIGs, several of which were predicted toencode redox-controlling proteins. They noted that reactive oxygenspecies (ROS) are potent inducers of apoptosis. Flow cytometricanalysis showed that p53 expression induces ROS production, whichincreases as apoptosis progresses under some conditions. Theauthors stated that the PIG10 gene, also called ENC1, encodes anactin-binding protein.
Other Names:
Ectoderm-neural cortex protein 1, ENC-1, Kelch-like protein 37, Nuclear matrix protein NRP/B, p53-induced gene 10 protein, ENC1, KLHL37, NRPB, PIG10
Gene Name: ENC1
Gene ID: 8507
Primary Accession: O14682
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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