ERBB4 (phospho-Y1284) polyclonal, anti-human, mouse, rat

Background:
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Synonyms: ALS19, HER4, p180erbB4

Cellular Location: Cell membrane Mitochondrion Nucleus Single-pass type I membrane protein

Immunogen:
A phospho specific peptide corresponding to residues surrounding Y1284 of human HER4

Gene Symbol: Phospho-ERBB4-Y1284

Gene ID: 2066

Swiss prot: Q15303

Calculated MW: 147kDa

Recommended dilution:
WB 1:500-2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.