ERF (phospho-T526) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4312
Background:
ABT1 (activator of basal transcription 1) is a nuclear protein that associates with the TATA-binding protein (TBP) and enhances basal transcription activity of class II promoters. ABT1 associates with TBP in HeLa nuclear extracts in vitro. Another protein, designated ERF, is a member of the Ets family of transcription factors. The members of the Ets family are grouped because they share a highly conserved DNA binding domain. These factors are involved in growth factor pathways and regulate both proliferation and differentiation. ERF (Ets-2 repressor factor) is a ubiquitously expressed Ets-domain protein that exhibits strong transcriptional repressor activity, suppresses Ets-induced transformation and is regulated by MAPK phosphorylation. ERF transcription may be regulated by Ets-domain proteins. Additionally, modulation of ERF activity is involved in the transcriptional regulation of genes activated during entry into G1 phase.
Alternative Name:
ERF, ERF, ETS domain containing transcription factor ERF, ETS domain-containing transcription factor ERF, Ets2 repressor factor, PE 2, PE-2, PE2,
Application Dilution: IHC: 1:50~1:200, IF: 1:50~1:200
Specificity: p-ERF (T526) polyclonal antibody detects endogenous levels of ERF only when phosphorylated at Thr526.
Immunogen:
Synthetic phosphopeptide derived from human ERF around the phosphorylation site of Threonine 526.
MW: ~ 59 kDa
Swis Prot.: P50548
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
ABT1 (activator of basal transcription 1) is a nuclear protein that associates with the TATA-binding protein (TBP) and enhances basal transcription activity of class II promoters. ABT1 associates with TBP in HeLa nuclear extracts in vitro. Another protein, designated ERF, is a member of the Ets family of transcription factors. The members of the Ets family are grouped because they share a highly conserved DNA binding domain. These factors are involved in growth factor pathways and regulate both proliferation and differentiation. ERF (Ets-2 repressor factor) is a ubiquitously expressed Ets-domain protein that exhibits strong transcriptional repressor activity, suppresses Ets-induced transformation and is regulated by MAPK phosphorylation. ERF transcription may be regulated by Ets-domain proteins. Additionally, modulation of ERF activity is involved in the transcriptional regulation of genes activated during entry into G1 phase.
Alternative Name:
ERF, ERF, ETS domain containing transcription factor ERF, ETS domain-containing transcription factor ERF, Ets2 repressor factor, PE 2, PE-2, PE2,
Application Dilution: IHC: 1:50~1:200, IF: 1:50~1:200
Specificity: p-ERF (T526) polyclonal antibody detects endogenous levels of ERF only when phosphorylated at Thr526.
Immunogen:
Synthetic phosphopeptide derived from human ERF around the phosphorylation site of Threonine 526.
MW: ~ 59 kDa
Swis Prot.: P50548
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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