ERK1 (phospho-T202/Y204 + ERK2 (phospho-T185/Y187) polyclonal, anti-human, mouse, rat

Background:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

Synonyms: ERK, p38, p40, p41, ERK2, ERT1, MAPK2, PRKM1, PRKM2, P42MAPK, p41mapk,

Cellular Location: Cytoskeleton Nucleus

Immunogen:
A phospho specific peptide corresponding to residues surrounding T202 of human ERK1

Gene Symbol: Phospho-ERK1-T202/Y204 + ERK2-T185/Y187

Gene ID: 5594/5595

Swiss prot: P28482; P27361

Calculated MW: 41kDa

Recommended dilution:
WB 1:500-2000, IP 1:50-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.