F11 polyclonal, anti-human
€305.00
In stock
SKU
BS60701
Background:
Coagulation Factor XI (FXI) is a glycoprotein produced by platelets and megakaryocytes in the liver and circulates as a zymogen homodimer in plasma. Factor XI is a trypsin-like plasma serine protease that catalyzes the activation of the consolidation phase of blood coagulation through a Thrombin-generated feedback loop. The plasma half-life of Factor XI is about 52 hours, and plasma concentrations are usually 5 mg/l. During hemostasis, the coagulation protease factor (Factor XIa) activates Factor XI. Factor XI deficiency (Hemophilia C) is an injury-related bleeding disorder that leads to a variable bleeding tendency which is inherited in an autosomal recessive manner, though is not completely recessive, because heterozygotes also have a mild but definite bleeding tendency.
Alternative Name:
Coagulation factor XI, FXI, Plasma thromboplastin antecedent, PTA, F11
Application Dilution: WB: 1:500~1:1000
Specificity: F11 polyclonal antibody detects endogenous levels of F11 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human F11
MW: ~ 70 kDa
Swis Prot.: P03951
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Coagulation Factor XI (FXI) is a glycoprotein produced by platelets and megakaryocytes in the liver and circulates as a zymogen homodimer in plasma. Factor XI is a trypsin-like plasma serine protease that catalyzes the activation of the consolidation phase of blood coagulation through a Thrombin-generated feedback loop. The plasma half-life of Factor XI is about 52 hours, and plasma concentrations are usually 5 mg/l. During hemostasis, the coagulation protease factor (Factor XIa) activates Factor XI. Factor XI deficiency (Hemophilia C) is an injury-related bleeding disorder that leads to a variable bleeding tendency which is inherited in an autosomal recessive manner, though is not completely recessive, because heterozygotes also have a mild but definite bleeding tendency.
Alternative Name:
Coagulation factor XI, FXI, Plasma thromboplastin antecedent, PTA, F11
Application Dilution: WB: 1:500~1:1000
Specificity: F11 polyclonal antibody detects endogenous levels of F11 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human F11
MW: ~ 70 kDa
Swis Prot.: P03951
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
| Is Featured? | No |
|---|
Write Your Own Review