F7 Polyclonal Antibody

Background:
This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Research Area: Cancer, Cardiovascular

Synonyms:
coagulation factor VII (serum prothrombin conversion accelerator), Coagulation factor VII, Eptacog alfa, F7, FA7, Factor VII, Factor VII heavy chain, Factor VII light chain, FVII coagulation protein, OTTHUMP00000018733, OTTHUMP00000018734, Proconvertin, Serum prothrombin conversion accelerator, SPCA

Immunogen: Recombinant protein of human F7

Swissprot: P08709
Gene Accession: BC130468

Calculated MW: 49 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.4 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:25-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-16343/sc-16344/sc-16347