Factor IX Polyclonal Antibody

Background:
This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease.

Research Area: Cardiovascular, Immunology

Synonyms:
Christmas Disease, Christmas factor, Coagulant factor IX, Coagulation factor 9, Coagulation factor IX, Coagulation factor IXa heavy chain, F9, FA9, Factor 9, Factor IX Deficiency, FactorIX, FIX, Haemophilia B, HEMB, MGC129641, MGC129642, P19, Plasma Thromboplastic Component, Plasma thromboplastin component, PTC

Immunogen: Recombinant protein of human F9

Swissprot: P00740
Gene Accession: BC109215

Calculated MW: 52 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.2 mg/mL
Dilution: WB 1:500-1:2000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-16337