FANCL Polyclonal Antibody

Background:
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
FANCL, FAAP43, PHF9, POG

Immunogen: Recombinant fusion protein of human FANCL (NP_060532.2).

Swissprot: Q9NW38
Gene ID: 55120

Calculated MW: 42 kDa/43 kDa
Observed MW: 38 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:200-1:2000 IHC 1:20-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.