FBXW4 Blocking Peptide (C-term)
€363.00
In stock
SKU
AC-BP20218B
Background:
This gene is a member of the F-box/WD-40 gene family,which recruit specific target proteins through their WD-40protein-protein binding domains for ubiquitin mediated degradation.In mouse, a highly similar protein is thought to be responsible formaintaining the apical ectodermal ridge of developing limb buds;disruption of the mouse gene results in the absence of centraldigits, underdeveloped or absent metacarpal/metatarsal bones andsyndactyly. This phenotype is remarkably similar to splithand-split foot malformation in humans, a clinically heterogeneouscondition with a variety of modes of transmission. An autosomalrecessive form has been mapped to the chromosomal region where thisgene is located, and complex rearrangements involving duplicationsof this gene and others have been associated with the condition. Apseudogene of this locus has been mapped to one of the introns ofthe BCR gene on chromosome 22.
Other Names:
F-box/WD repeat-containing protein 4, Dactylin, F-box and WD-40 domain-containing protein 4, FBXW4, FBW4, SHFM3
Target/Specificity:
The synthetic peptide sequence is selected from aa 356-370 of HUMAN FBXW4
Gene Name: FBXW4
Gene ID: 6468
Primary Accession: P57775
Other Accession: NP_071322.1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene is a member of the F-box/WD-40 gene family,which recruit specific target proteins through their WD-40protein-protein binding domains for ubiquitin mediated degradation.In mouse, a highly similar protein is thought to be responsible formaintaining the apical ectodermal ridge of developing limb buds;disruption of the mouse gene results in the absence of centraldigits, underdeveloped or absent metacarpal/metatarsal bones andsyndactyly. This phenotype is remarkably similar to splithand-split foot malformation in humans, a clinically heterogeneouscondition with a variety of modes of transmission. An autosomalrecessive form has been mapped to the chromosomal region where thisgene is located, and complex rearrangements involving duplicationsof this gene and others have been associated with the condition. Apseudogene of this locus has been mapped to one of the introns ofthe BCR gene on chromosome 22.
Other Names:
F-box/WD repeat-containing protein 4, Dactylin, F-box and WD-40 domain-containing protein 4, FBXW4, FBW4, SHFM3
Target/Specificity:
The synthetic peptide sequence is selected from aa 356-370 of HUMAN FBXW4
Gene Name: FBXW4
Gene ID: 6468
Primary Accession: P57775
Other Accession: NP_071322.1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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