GEN1 polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS70580
Background:
GEN1 (flap endonuclease GEN homolog 1) is a 908 amino acid nuclear protein that belongs to the XPG/RAD2 endonuclease family and GEN subfamily. GEN1 cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA and binds two magnesium ions per subunit. The gene encoding GEN1 maps to human chromosome 2, which consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstrom syndrome is due to mutations in the ALMS1 gene
Alternative Name:
Flap endonuclease GEN homolog 1
Application Dilution: WB: 1:500 - 1:2000
Specificity: GEN1 polyclonal antibody detects endogenous levels of GEN1 protein.
Immunogen:
Recombinant protein of human GEN1.
MW: ~ 102 kDa
Swis Prot.: Q17RS7
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
GEN1 (flap endonuclease GEN homolog 1) is a 908 amino acid nuclear protein that belongs to the XPG/RAD2 endonuclease family and GEN subfamily. GEN1 cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA and binds two magnesium ions per subunit. The gene encoding GEN1 maps to human chromosome 2, which consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstrom syndrome is due to mutations in the ALMS1 gene
Alternative Name:
Flap endonuclease GEN homolog 1
Application Dilution: WB: 1:500 - 1:2000
Specificity: GEN1 polyclonal antibody detects endogenous levels of GEN1 protein.
Immunogen:
Recombinant protein of human GEN1.
MW: ~ 102 kDa
Swis Prot.: Q17RS7
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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