GP6 Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP5691b
Background:
Glycoprotein VI (GP6) is a 58-kD platelet membraneglycoprotein that plays a crucial role in the collagen-inducedactivation and aggregation of platelets. Upon injury to the vesselwall and subsequent damage to the endothelial lining, exposure ofthe subendothelial matrix to blood flow results in deposition ofplatelets. Collagen fibers are the most thrombogenic macromolecularcomponents of the extracellular matrix, with collagen types I, III,and VI being the major forms found in blood vessels. Plateletinteraction with collagen occurs as a 2-step procedure: (1) theinitial adhesion to collagen is followed by (2) an activation stepleading to platelet secretion, recruitment of additional platelets,and aggregation. In physiologic conditions, the resulting plateletplug is the initial hemostatic event limiting blood loss. However,exposure of collagen after rupture of atherosclerotic plaques is amajor stimulus of thrombus formation associated with myocardialinfarction or stroke (Jandrot-Perrus et al., 2000 [PubMed10961879]).
Other Names:
Platelet glycoprotein VI, GPVI, Glycoprotein 6, GP6
Gene Name: GP6 (HGNC:14388)
Gene ID: 51206
Primary Accession: Q9HCN6
Other Accession: NP_057447.4
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Glycoprotein VI (GP6) is a 58-kD platelet membraneglycoprotein that plays a crucial role in the collagen-inducedactivation and aggregation of platelets. Upon injury to the vesselwall and subsequent damage to the endothelial lining, exposure ofthe subendothelial matrix to blood flow results in deposition ofplatelets. Collagen fibers are the most thrombogenic macromolecularcomponents of the extracellular matrix, with collagen types I, III,and VI being the major forms found in blood vessels. Plateletinteraction with collagen occurs as a 2-step procedure: (1) theinitial adhesion to collagen is followed by (2) an activation stepleading to platelet secretion, recruitment of additional platelets,and aggregation. In physiologic conditions, the resulting plateletplug is the initial hemostatic event limiting blood loss. However,exposure of collagen after rupture of atherosclerotic plaques is amajor stimulus of thrombus formation associated with myocardialinfarction or stroke (Jandrot-Perrus et al., 2000 [PubMed10961879]).
Other Names:
Platelet glycoprotein VI, GPVI, Glycoprotein 6, GP6
Gene Name: GP6 (HGNC:14388)
Gene ID: 51206
Primary Accession: Q9HCN6
Other Accession: NP_057447.4
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
| Is Featured? | No |
|---|
Write Your Own Review