Guanylate kinase (GUK1) Antibody (Center) Blocking peptide
€363.00
In stock
SKU
AC-BP7070b
Background:
Guanylate kinase catalyzes the transfer of phosphate from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) or dGMP. This enzyme functions in the recovery of cGMP and is, therefore, thought to regulate the supply of guanine nucleotides to signal transduction pathways. The GUK2 and GUK3 isoforms are determined by separate loci. Brady et al. (1996) cloned human and mouse cDNAs of GUK1. They stated that the guanylate kinases are targets for cancer chemotherapy and are inhibited by the antitumor drug 6-thioguanine. They reported that the human gene codes for a protein of 197 amino acids with a mass of 21.7 kD. They found that the 1-kb message was ubiquitously expressed.
Other Names:
Guanylate kinase, GMP kinase, GUK1, GMK
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7070b was selected from the Center region of human GUK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: GUK1 {ECO:0000303|PubMed:8647247, ECO:0000312|HGNC:HGNC:4693}
Gene ID: 2987
Primary Accession: Q16774
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Guanylate kinase catalyzes the transfer of phosphate from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) or dGMP. This enzyme functions in the recovery of cGMP and is, therefore, thought to regulate the supply of guanine nucleotides to signal transduction pathways. The GUK2 and GUK3 isoforms are determined by separate loci. Brady et al. (1996) cloned human and mouse cDNAs of GUK1. They stated that the guanylate kinases are targets for cancer chemotherapy and are inhibited by the antitumor drug 6-thioguanine. They reported that the human gene codes for a protein of 197 amino acids with a mass of 21.7 kD. They found that the 1-kb message was ubiquitously expressed.
Other Names:
Guanylate kinase, GMP kinase, GUK1, GMK
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7070b was selected from the Center region of human GUK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: GUK1 {ECO:0000303|PubMed:8647247, ECO:0000312|HGNC:HGNC:4693}
Gene ID: 2987
Primary Accession: Q16774
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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