GUSB polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61590
Background:
The enzyme β-glucuronidase catalyzes the conversion of β-D-glucuronoside and water to an alcohol and D-glucuronate. Deficiency of β-glucuronidase is the cause of the human lysosomal storage disorder mucopolysaccharidosis type VII (MPS VII). Specifically, two residues appear important for catalytic activity: Glu 451 and Glu 540. Mutations at these sites affect the overall structure of the protein, which normally consists of a homotetramer with each promoter including a jelly roll barrel, an immunoglobulin constant domain and a TIM barrel. Regulation of β-glucuronidase activity may play a role in tumorigenesis and the invasiveness of a number of cancers, and is also an important factor in the development of functional prodrugs that require the cleavage of an active cytostatic by endogenous enzymes for antitumor activity.
Alternative Name:
asd, Beta G1, Beta glucuronidase, Beta-G1, Beta-glucuronidase, BG, BGLR, BGLR_HUMAN, FLJ39445, Glucuronidase beta, Gur, Gus, Gus-r, Gus-s, Gus-t, Gus-u, GUSB, Gut, MPS7
Application Dilution: WB: 1:500~1:1000
Specificity: GUSB polyclonal antibody detects endogenous levels of GUSB protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 324-368 of Human GUSB.
MW: ~ 74 kDa
Swis Prot.: P08236
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The enzyme β-glucuronidase catalyzes the conversion of β-D-glucuronoside and water to an alcohol and D-glucuronate. Deficiency of β-glucuronidase is the cause of the human lysosomal storage disorder mucopolysaccharidosis type VII (MPS VII). Specifically, two residues appear important for catalytic activity: Glu 451 and Glu 540. Mutations at these sites affect the overall structure of the protein, which normally consists of a homotetramer with each promoter including a jelly roll barrel, an immunoglobulin constant domain and a TIM barrel. Regulation of β-glucuronidase activity may play a role in tumorigenesis and the invasiveness of a number of cancers, and is also an important factor in the development of functional prodrugs that require the cleavage of an active cytostatic by endogenous enzymes for antitumor activity.
Alternative Name:
asd, Beta G1, Beta glucuronidase, Beta-G1, Beta-glucuronidase, BG, BGLR, BGLR_HUMAN, FLJ39445, Glucuronidase beta, Gur, Gus, Gus-r, Gus-s, Gus-t, Gus-u, GUSB, Gut, MPS7
Application Dilution: WB: 1:500~1:1000
Specificity: GUSB polyclonal antibody detects endogenous levels of GUSB protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 324-368 of Human GUSB.
MW: ~ 74 kDa
Swis Prot.: P08236
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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