HAS2 Antibody (Center) Blocking peptide
€363.00
In stock
SKU
AC-BP5687c
Background:
Hyaluronan or hyaluronic acid (HA) is a high molecularweight unbranched polysaccharide synthesized by a wide variety oforganisms from bacteria to mammals, and is a constituent of theextracellular matrix. It consists of alternating glucuronic acidand N-acetylglucosamine residues that are linked by beta-1-3 andbeta-1-4 glycosidic bonds. HA is synthesized by membrane-boundsynthase at the inner surface of the plasma membrane, and thechains are extruded through pore-like structures into theextracellular space. It serves a variety of functions, includingspace filling, lubrication of joints, and provision of a matrixthrough which cells can migrate. HA is actively produced duringwound healing and tissue repair to provide a framework for ingrowthof blood vessels and fibroblasts. Changes in the serumconcentration of HA are associated with inflammatory anddegenerative arthropathies such as rheumatoid arthritis. Inaddition, the interaction of HA with the leukocyte receptor CD44 isimportant in tissue-specific homing by leukocytes, andoverexpression of HA receptors has been correlated with tumormetastasis. HAS2 is a member of the newly identified vertebrategene family encoding putative hyaluronan synthases, and its aminoacid sequence shows significant homology to glycosaminoglycansynthetase (DG42) from Xenopus laevis, and human and murinehyaluronan synthase 1.
Other Names:
Hyaluronan synthase 2, Hyaluronate synthase 2, Hyaluronic acid synthase 2, HA synthase 2, HAS2
Gene Name: HAS2 (HGNC:4819)
Gene ID: 3037
Primary Accession: Q92819
Other Accession: NP_005319.1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Hyaluronan or hyaluronic acid (HA) is a high molecularweight unbranched polysaccharide synthesized by a wide variety oforganisms from bacteria to mammals, and is a constituent of theextracellular matrix. It consists of alternating glucuronic acidand N-acetylglucosamine residues that are linked by beta-1-3 andbeta-1-4 glycosidic bonds. HA is synthesized by membrane-boundsynthase at the inner surface of the plasma membrane, and thechains are extruded through pore-like structures into theextracellular space. It serves a variety of functions, includingspace filling, lubrication of joints, and provision of a matrixthrough which cells can migrate. HA is actively produced duringwound healing and tissue repair to provide a framework for ingrowthof blood vessels and fibroblasts. Changes in the serumconcentration of HA are associated with inflammatory anddegenerative arthropathies such as rheumatoid arthritis. Inaddition, the interaction of HA with the leukocyte receptor CD44 isimportant in tissue-specific homing by leukocytes, andoverexpression of HA receptors has been correlated with tumormetastasis. HAS2 is a member of the newly identified vertebrategene family encoding putative hyaluronan synthases, and its aminoacid sequence shows significant homology to glycosaminoglycansynthetase (DG42) from Xenopus laevis, and human and murinehyaluronan synthase 1.
Other Names:
Hyaluronan synthase 2, Hyaluronate synthase 2, Hyaluronic acid synthase 2, HA synthase 2, HAS2
Gene Name: HAS2 (HGNC:4819)
Gene ID: 3037
Primary Accession: Q92819
Other Accession: NP_005319.1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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